整合医学“科学论坛”系列讲座之神经发育与再生

时    间:2017年6月30日下午14:00-17:00

地    点:图书馆305会议室

论坛主席:顾晓松 院士

题    目:神经发育与再生

主 讲 人:美国宾西法尼亚大学  宋洪军、明国莉 教授

简    介:

宋洪军 教授 获北京大学学士学位、1995年获美国哥伦比亚大学生物学硕士学位、1998年获美国加利福尼亚大学圣地亚哥分校生物学博士学位,1998-2002年在美国索尔克研究院霍华德•休斯从事博士后研究, 2003-2007 Johns Hopkins大学医学院神经科学系细胞工程研究院助理教授, 2007年起任美国Johns Hopkins大学医学院副教授。2010年起担任约翰霍普金斯大学医学院神经学教授、细胞工程研究所干细胞项目负责人。2017年3月,担任美国宾夕法尼亚大学医学院终身教授。

明国莉 教授 获上海医科大学医学学士学位,美国加利福尼亚大学圣地亚哥分校生物学博士学位,曾担任约翰霍普金斯大学医学院神经学教授。2017年3月,担任美国宾夕法尼亚大学医学院终身教授。主要研究领域:神经发育,神经生物学等。

近五年代表性论著:

1. Kim JY, Liu CY, Zhang F, Duan X, Wen Z, Song J, Feighery E, Lu B, Rujescu D, St Clair D, Christian K, Callicott JH, Weinberger DR, Song H and Ming GL. Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell. 2012; 148(5):1051-1064.

2. Shin J, Ming GL and Song H. By hook or by crook: multifaceted DNA-binding properties of MeCP2. Cell. 2013; 152(5):940-942.

3. Song J, Zhong C, Bonaguidi MA, Sun GJ, Hsu D, Gu Y, Meletis K, Huang ZJ, Ge S, Enikolopov G, Deisseroth K, Luscher B, Christian KM, Ming GL and Song H. Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature. 2012; 489(7414):150-154.

4. Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, et al. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature. 2014; 515(7527):414-418.

5. Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, et al. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science (New York, NY). 2016; 354(6308).

6. Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, Allen C, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature medicine. 2016; 22(10):1101-1107.

7. Bond AM, Ming GL and Song H. Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later. Cell stem cell. 2015; 17(4):385-395.

8. Jang MH, Bonaguidi MA, Kitabatake Y, Sun J, Song J, Kang E, Jun H, Zhong C, Su Y, Guo JU, Wang MX, Sailor KA, Kim JY, Gao Y, Christian KM, Ming GL, et al. Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell stem cell. 2013; 12(2):215-223.

9. Ming GL, Tang H and Song H. Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities. Cell stem cell. 2016; 19(6):690-702.

10.Shin J, Berg DA, Zhu Y, Shin JY, Song J, Bonaguidi MA, Enikolopov G, Nauen DW, Christian KM, Ming GL and Song H. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell stem cell. 2015; 17(3):360-372.

11.Yoon KJ, Nguyen HN, Ursini G, Zhang F, Kim NS, Wen Z, Makri G, Nauen D, Shin JH, Park Y, Chung R, Pekle E, Zhang C, Towe M, Hussaini SM, Lee Y, et al. Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell stem cell. 2014; 15(1):79-91.

12.Ming GL, Song H, Shin J, Ming GL and Song H. Molecular toggle switch of histone demethylase LSD1. Nature neuroscience. 2015; 57(6):949-950.

13.Roychowdhury P, Lim J, Kim D, Ming GL, Song H, Beckervordersandforth R, Ebert B, Schaffner I, Moss J, Fiebig C, Shin J, Moore DL, Ghosh L, Trinchero MF, Stockburger C, Friedland K, et al. Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Nature neuroscience. 2017; 93(3):560-573.e566.

14.Shin J, Ming GL and Song H. Decoding neural transcriptomes and epigenomes via high-throughput sequencing. Nature neuroscience. 2014; 17(11):1463-1475.

15.Sun GJ, Zhou Y, Ito S, Bonaguidi MA, Stein-O'Brien G, Kawasaki NK, Modak N, Zhu Y, Ming GL and Song H. Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. Nature neuroscience. 2015; 18(12):1722-1724.

16.Zhu H, Chang Q, Gao Y, Ming GL, Song H, Song J, Sun J, Moss J, Wen Z, Sun GJ, Hsu D, Zhong C, Davoudi H, Christian KM, Toni N, Ming GL, et al. Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nature neuroscience. 2013; 16(12):1728-1730.

17.Yao B, Christian KM, He C, Jin P, Ming GL and Song H. Epigenetic mechanisms in neurogenesis. Nature reviews Neuroscience. 2016; 17(9):537-549.

18.Song H and Ming GL. Reprogram to pluripotency: a new logic and a chemical cocktail. National science review. 2014; 1(1):6-7.

19.Huang W, Ming GL and Song H. Experience matters: enrichment remodels synaptic inputs to adult-born neurons. Neuron. 2015; 85(4):659-661.

20.Shin J, Ming GL and Song H. Seeking a roadmap toward neuroepigenetics. Neuron. 2015; 86(1):12-15.

21.Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H and Ming GL. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017; 94(2):337-346.e336.

22.Song J, Christian KM, Ming GL and Song H. Life or death: developing cortical interneurons make their own decision. The EMBO journal. 2012; 31(23):4373-4374.

23.Wen Z, Song H and Ming GL. How does Zika virus cause microcephaly? Genes & development. 2017; 31(9):849-861.

24.Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM, Christian KM, Didier RA, Jin P, Song H and Ming GL. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Nature communications. 2016; 18(5):587-590.

25.Sun GJ, Zhou Y, Stadel RP, Moss J, Yong JH, Ito S, Kawasaki NK, Phan AT, Oh JH, Modak N, Reed RR, Toni N, Song H and Ming GL. Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(30):9484-9489.

 

整合医学学院 

整合医学研究院

2017年6月23日